Quercetin, a flavonoid abundant in various fruits and vegetables, offers several benefits for stabilizing mast cells and lowering tryptase levels, which in turn can have positive effects on fascia, muscle, connective tissue health, and gastrointestinal (GI) function:

  1. Stabilizing Mast Cells: Mast cells are immune cells involved in allergic and inflammatory responses. When mast cells become overly activated, they release inflammatory mediators, including histamine and tryptase. Quercetin has been shown to stabilize mast cells, preventing excessive activation and the release of these inflammatory compounds.
  2. Lowering Tryptase Levels: Tryptase is an enzyme predominantly released by mast cells during allergic and inflammatory reactions. Elevated levels of tryptase can contribute to tissue breakdown by promoting inflammation and tissue remodeling. Quercetin inhibits tryptase activity, thereby helping to lower tryptase levels and mitigate its detrimental effects on fascia, muscle, and connective tissue integrity.
  3. Impact on Fascia, Muscle, and Connective Tissue: Tryptase, when overproduced, can contribute to the breakdown of fascia, muscle, and connective tissue by promoting inflammation and tissue remodeling. By stabilizing mast cells and lowering tryptase levels, quercetin helps protect these tissues from degradation, supporting their structural integrity and function.
  4. Histamine Regulation: Mast cells also release histamine, a potent inflammatory mediator that can cause inflammation and pain. Quercetin’s ability to stabilize mast cells helps regulate histamine release, reducing the risk of excessive inflammation and associated discomfort in fascia, muscle, and connective tissues.
  5. Gastrointestinal Function: Mast cells are abundant in the GI tract and play a crucial role in regulating gut function. Dysregulated mast cell activation can lead to GI symptoms such as abdominal pain, cramping, diarrhea, and bloating. Quercetin’s mast cell-stabilizing properties help prevent excessive release of inflammatory mediators in the GI tract, thereby alleviating GI discomfort and promoting normal bowel function. Additionally, quercetin helps maintain intestinal barrier integrity, reduces intestinal permeability, and supports balanced gut motility, contributing to overall GI health.

In summary, quercetin’s ability to stabilize mast cells and lower tryptase levels not only benefits fascia, muscle, and connective tissue health by reducing inflammation and tissue breakdown but also supports gastrointestinal function by alleviating GI symptoms and promoting digestive health. Incorporating quercetin-rich foods or supplements may be beneficial for individuals seeking to improve both musculoskeletal and GI health.

Our Recommendation:

Weng Z, Zhang B, Asadi S, Sismanopoulos N, Butcher A, Fu X, Katsarou-Katsari A, Antoniou C, Theoharides TC. Quercetin is more effective than cromolyn in blocking human mast cell cytokine release and inhibits contact dermatitis and photosensitivity in humans. PLoS One. 2012;7(3):e33805. doi: 10.1371/journal.pone.0033805. Epub 2012 Mar 28. PMID: 22470478; PMCID: PMC3314669.

Theoharides TC, Tsilioni I, Ren H. Recent advances in our understanding of mast cell activation – or should it be mast cell mediator disorders? Expert Rev Clin Immunol. 2019 Jun;15(6):639-656. doi: 10.1080/1744666X.2019.1596800. Epub 2019 Apr 22. PMID: 30884251; PMCID: PMC7003574.

The above supplements are generalized recommendations from FullScript and are not meant to treat any specific disease of any patient we have not had the opportunity to evaluate at The Fascia Institute and Treatment Center. At the time of this post, purchases made through this site will receive a 10% discount. The Fascia Institute and Treatment Center is an affiliate of FullScript and proceeds are used to support clinical processes.