Importance of Taking Methylated Folate and B12

Let’s delve into why taking methylated supplements is important for individuals with an MTHFR mutation, particularly concerning fascia, muscle, and connective tissue health:

  1. MTHFR Mutation and Methylation Process: MTHFR (methylenetetrahydrofolate reductase) is an enzyme involved in the methylation process, which is essential for various biochemical reactions in the body. Methylation plays a crucial role in DNA synthesis and repair, neurotransmitter production, hormone regulation, and immune function.
  2. Impact on Tissue Health: Fascia, muscles, and connective tissues rely on optimal methylation for their health and function. Methylation processes are involved in regulating gene expression, repairing DNA damage, and producing important molecules that support tissue repair, growth, and maintenance.
  3. Reduced Enzyme Activity: Individuals with an MTHFR mutation have a genetic variation that results in reduced enzyme activity. This impairment can lead to challenges in effectively processing folate and other B vitamins, which are essential for methylation.
  4. Potential Consequences: Impaired methylation due to an MTHFR mutation can have various consequences for fascia, muscle, and connective tissue health. It may lead to increased susceptibility to injuries, delayed recovery times, and compromised tissue integrity. Additionally, inadequate methylation can contribute to inflammation and oxidative stress, further impacting tissue health.
  5. Methylated Supplements: Methylated supplements provide active forms of vitamins, such as methylfolate (active form of folate) and methylcobalamin (active form of vitamin B12), that bypass the need for MTHFR to convert them into their active states. By providing these methylated nutrients directly, individuals with an MTHFR mutation can support methylation pathways and mitigate the effects of impaired enzyme activity.
  6. Supporting Tissue Health: Incorporating methylated supplements into the daily regimen can help support the health and function of fascia, muscles, and connective tissues in individuals with an MTHFR mutation. These supplements can contribute to better tissue repair, resilience, and overall well-being.

In summary, taking methylated supplements is crucial for individuals with an MTHFR mutation to support the methylation process and maintain the health of fascia, muscles, and connective tissues. By addressing potential deficiencies and supporting optimal methylation, individuals can mitigate the impact of genetic variation on tissue health and function.

Our Recommendation

Boost Methylation with Choline

Choline is an essential nutrient that plays a critical role in various physiological processes, including methylation, brain health, and connective tissue health. Here’s how choline is involved in each of these areas:

  1. Methylation: Choline is a precursor to betaine, which is involved in a metabolic pathway called the choline cycle. In this cycle, choline is converted to betaine through a series of enzymatic reactions. Betaine, in turn, participates in the donation of methyl groups for methylation reactions in the body. Methylation is a fundamental biochemical process involved in various cellular functions, including DNA synthesis and repair, neurotransmitter synthesis, hormone regulation, and detoxification. By providing methyl groups, choline contributes to methylation processes essential for maintaining overall health and well-being.
  2. Brain Health: Choline is a key component of cell membranes and is necessary for the synthesis of the neurotransmitter acetylcholine. Acetylcholine is involved in numerous cognitive functions, including memory, learning, and muscle control. Adequate choline intake is crucial for optimal brain development and function, particularly during fetal development and early childhood. Choline deficiency has been associated with cognitive impairment, neural tube defects, and neurodegenerative diseases such as Alzheimer’s disease. By supporting acetylcholine synthesis and brain cell membrane integrity, choline promotes brain health and cognitive function throughout life.
  3. Connective Tissue Health: Choline is involved in the synthesis of phospholipids, which are major components of cell membranes and play a vital role in maintaining the structure and function of connective tissues. Phospholipids are abundant in cell membranes of connective tissue cells such as fibroblasts, which are responsible for producing collagen, elastin, and other extracellular matrix components. Choline deficiency can impair phospholipid synthesis, leading to compromised cell membrane integrity and connective tissue dysfunction. Ensuring an adequate intake of choline is essential for supporting the health and integrity of connective tissues throughout the body.

In summary, choline is involved in methylation processes, brain health, and connective tissue health through its roles in betaine synthesis, acetylcholine production, and phospholipid synthesis, respectively. Including choline-rich foods in the diet or supplementing with choline may help support overall health and well-being, including brain function and the integrity of connective tissues.

Our Recommendation


The above supplements are generalized recommendations from FullScript and are not meant to treat any specific disease of any patient we have not had the opportunity to evaluate at The Fascia Institute and Treatment Center. At the time of this post, purchases made through this site will receive a 10% discount. The Fascia Institute and Treatment Center is an affiliate of FullScript and proceeds are used to support clinical processes.