Jacques Courseault, MD, CAQSM, FAAPMR
August 26, 2022 – The area of hypermobility and Ehlers-Danlos research is gaining more traction with the recognition of peculiar clinically presenting patterns in flexible patients. Because of the thorough evaluation performed at the Tulane Hypermobility and Ehlers-Danlos Clinic, we noticed a trend of high folate levels during the screening. To explain the significance levels, we checked for MTHFR polymorphisms and noted an interesting trend. High folate levels correlate with MTHFR polymorphisms. We then teamed up with Dr. Gregory Bix to determine if folate has a relationship with extracellular matrix products. We have reported a connection between low intracellular folate and inactivated decorin (a protein necessary for the “glue that holds collagen together”).
This is very early research, and we are the first to publish this connection. Here is access to our peer-reviewed paper.
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